Semaglutide is a GLP-1 agonist that mimics gut hormones that our body naturally produces after meals. These hormones help with weight regulation by decreasing appetite and cravings in the brain and slowing stomach emptying so increase feelings of fullness and enhance insulin release and sensitivity in the body

M.O.A for both injections:

Gut

  • Decreases gastric emptying & peristalsis, thus normalizes PPG (postprandial glucose) elevations

Pancreas

  • Increases insulin secretion
  • Increases & protects pancreatic β cells
  • Decreases glucagon

Systematic

  • Control blood sugar level

Liver

  • Decreases hepatic glucose production
  • Decreases ectopic lipid accumulation

Central

  • Decreases appetite, increases satiety

Fat cells

  • lipolysis

Used once weekly for treatment of DM-2, and for weight loss.

• Nausea, vomiting, abdominal pain, diarrhea, constipation, gas, skin reactions, headaches and fatigue. These symptoms pass within a few days
• diarrhea, nausea, and vomiting may cause a loss of fluids and dehydration, which may cause kidney problems to get worse so drink many fluids (AKI)
• Pancreatitis, Stop using if you have severe pain in abdomen that will not go away, with or without vomiting. (ttt: pain relief, liquid food, iv fluids) (Cause: stimulation of GLP receptors that are expressed in islets and exocrine ducts of pancrease lead to overgrowth of cells causing hyperplasia and acute inflammation) how to avoid>> doses should be gradually increased.
• Gallbladder problems. Symptoms include: pain in your upper stomach, fever, jaundice, or clay-colored stools.
• lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath (probability of thyroid cancer)
• increased heart rate
• Changes in vision.

• Personal or family history of MTC or MEN2
• Pregnancy and lactation
• Diabetic neuropathy due to change in vision
• DM-1 (has not been evaluated for use in combination with prandial insulin.)

• Elevated HR patients , as there are GLP-1 receptors in the SA Node (may cause tachycardia)
• Patients on sulphonylurea due to risk of hypoglycemia

• Act as a direct messenger of the insulin signaling and improves glucose tissue uptake so improve insulin resistance

• Improves insulin resistance, decreases cholesterol, triglycerides, and blood pressure in people with metabolic syndrome.
• Improves blood sugar, ovulation, and pregnancy rates in people with PCOS.

• Diarrhea, gas, and nausea

The active substance in procut is tirzepatide, it attaches to a receptor of two hormones called glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) that are produced in the gut. It acts in the same way as GIP and GLP-1 by increasing the amount of insulin that the pancreas releases in response to food. This helps with the control of blood glucose levels.
It works similarly to uncut but it contains GIP receptor agonist in addition to a GLP-1 receptor agonist. That means it works by stimulating release of not one, but two unique incretin hormones produced by the human body. Thus it’s more effective in controlling blood sugar level

Patients have lost more weight in the same period of time, felt a heavier suppression of appetite, and showed fewer side effects. In addition to a greater decrease in HbA1c than uncut.

Used once weekly for treatment of DM-2, and for weight loss.

  • • The starting dose is 10u and the max dose is 50u
    • Each 1ml procut contains 30mg Tirzepatide

• Birth control pills may not work as well while using tirzepatide. Healthcare provider may switch to a non-oral birth control method for four weeks after starting the drug and four weeks after each dose escalation